Wham is suitable for paired-stop Illumina libraries with typical insert dimensions (~300bp-500bp). Wham integrates mate-pair mapping, split go through mapping, delicate-clipping, choice alignment and consensus sequence based proof to forecast SV breakpoints with single-nucleotide accuracy. Wham generates a put together pileup (catalog of reads mask
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The gentle-clipped sequences that overhang the breakpoint are collapsed right into a consensus sequence employing a many sequence alignment (MSA) supplied while in the seqAn library [27]. Wham applies 3 filters to your consensus sequences. Breakpoints are usually not noted in cases wherever consensus sequences are shorter than 10 bp or contain much